Bitsend looks like it may go through another retracement. For the most profitable strategy, I would say a long hold that is at least 3 to 4 month before any sustainable gains. I would also say that it is a medium to high risk investment given its protocol's competition. Bitsend is still at its core 0.14 version and can though make lots of room for improvement where it is a more Conservative investment strategy in the long run. Right now though, they seem to be growing and have some potential after the segwit soft fork completion.